InsightRX Data Science

clinPK

Provides equations commonly used in clinical pharmacokinetics and clinical pharmacology, such as equations for dose individualization, compartmental pharmacokinetics, drug exposure, anthropomorphic calculations, clinical chemistry, and conversion of common clinical parameters.

PKPDsim

Simulates dose regimens for pharmacokinetic-pharmacodynamic (PK-PD) models described by differential equation systems.

PKPDmap

Allows estimation of individual MAP Bayes estimates, based on population PK-PD models and collected clinical data.

mipdtrial

Easily simulates pharmacokinetic/ pharmacodynamic (PK/PD) endpoints in response to dose adaptation.

mipdeval

Evaluate predictive performance of PK/PD models in historical datasets, in the context of model-informed precision dosing (specifically Bayesian updating).

PKPD
posterior

Provides convenience functions around Stan, Torsten, and PKPDsim. The goal of the package is to make it easier to perform full-Bayesian inference in the context of model-informed precision dosing.